Focal brain cooling suppresses periodic epileptiform discharges and lessens brain injury after cerebral ischemia in rats

  • HE Yeting (Department of Neurosurgery, Graduate School of Medicine, Yamaguchi University)
  • FUJII Masami (Department of Neurosurgery, Graduate School of Medicine, Yamaguchi University)
  • INOUE Takao (Department of Neurosurgery, Graduate School of Medicine, Yamaguchi University)
  • NOMURA Sadahiro (Department of Neurosurgery, Graduate School of Medicine, Yamaguchi University)
  • KIDA hiroyuki (Department of Systems Neuroscience, Graduate School of Medicine, Yamaguchi University)
  • MARUTA Yuichi (Department of Neurosurgery, Graduate School of Medicine, Yamaguchi University)
  • KUNITSUGU Ichiro (Department of Public Health, Graduate School of Medicine, Yamaguchi University)
  • YAMAKAWA Takeshi (Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology)
  • SUZUKI Michiyasu (Department of Neurosurgery, Graduate School of Medicine, Yamaguchi University)

The aim of this study was to investigate whether Focal Brain Cooling (FBC) has a favorable effect on cerebral ischemic lesion in rats. Under general anesthesia, focal cerebral ischemia was induced with the photothrombosis technique. FBC was performed at a temperature of 15°C for 5 h. ECoG were recorded to confirm epileptiform discharges. In addition, neurobehavioral testing and grip strength testing was performed for 5days after ischemia. FBC suppressed all the ECoG frequency bands during and after cooling. Lesion size was significantly reduced and neurological deficits were improved by the cooling. These results suggest that FBC has potential for treatment of cerebral infarction.
Last-modified: 2012-12-18 (火) 15:56:32